Insulin Sensitivity, Body Fat Distribution, and Family Diabetes History: The IRAS Family Study
نویسندگان
چکیده
منابع مشابه
Insulin sensitivity, insulin secretion, and abdominal fat: the Insulin Resistance Atherosclerosis Study (IRAS) Family Study.
The relationship between insulin sensitivity and overall obesity is well established. However, there remains debate as to which of the fat depots, visceral abdominal tissue (VAT) or subcutaneous abdominal tissue (SAT), is of greater importance. Also, the relationship between fat distribution and insulin secretion is largely unknown. We studied SI, acute insulin response (AIR), and disposition i...
متن کاملUnique effect of visceral fat on insulin sensitivity in obese Hispanic children with a family history of type 2 diabetes.
OBJECTIVE This study aimed to establish whether total fat or central fat was related to measures of insulin in obese Hispanic children with a family history of type 2 diabetes. RESEARCH DESIGN AND METHODS Subjects were 32 children aged 8-13 years. Visceral fat and subcutaneous abdominal fat were determined by magnetic resonance imaging at the umbilicus and total body fat was determined by dua...
متن کاملFamily history of diabetes mellitus determines insulin sensitivity and beta cell function in polycystic ovary syndrome.
OBJECTIVE To examine the impact of family history of diabetes mellitus 2 (DM 2) on insulin sensitivity and secretion in lean women with polycystic ovary syndrome (PCOS). Thirteen healthy women (C), 14 PCOS without family history of DM 2 (FH-) and 8 PCOS with family history of DM 2 (FH+) were examined using euglycemic hyperinsulinemic clamp and an arginine secretion test (insulin and glucagon at...
متن کاملInfluence of family history of type 2 diabetes on insulin sensitivity in prepubertal children.
The objective of this study was to examine the influence of positive family history (FH) of type 2 diabetes (T2D) on aspects of insulin resistance in prepubertal children. Twenty-one children (Tanner stage I or II) with a positive FH were compared with children with no FH. FH was defined by presence of T2D in a parent or grandparent as assessed by interview. The two groups of children were matc...
متن کاملSleep duration and five-year abdominal fat accumulation in a minority cohort: the IRAS family study.
STUDY OBJECTIVES To study 5-year change in computed tomography (CT)-derived visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) associated with sleep duration in 2 minority groups. DESIGN Longitudinal epidemiologic study. SETTING Three US communities. PARTICIPANTS African Americans (N = 332) and Hispanic Americans (N = 775), aged 18-81 years, participating in the IRAS Fami...
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ژورنال
عنوان ژورنال: Obesity Research
سال: 2004
ISSN: 1071-7323
DOI: 10.1038/oby.2004.100